Cafepime and the other three third generation cephalosporins were tested for their antimicrobial effects. Minimal Inibitory concentrations of total 407 clinical isolates were determined by the agar dilution method. Cefepime showed the lowest
MIC90
against Citrobacter freundii and Enterobacter cloacae, 1ug/ml and 8ug/ml respectively. MIC90 of cefepime, 16ug/ml, was the lowest against Pseudomonas aeruginosa and Acinetobacter calcoaceticus. Cefepime showed the lowest MIC90 against Serratia
marcescens and oxacillin sensitive Staphylococcus aureus. Against Klebsiella pneumoniae, cefepime showed low MIC90 0.5ug/ml. MIC90 of cefepime, 16ug/ml, was the lowest against Streptococcus species. However, cefepime showed high MIC90 against
Xanthomonas maltophilia, oxacillin resistant Staphylococcus aureus and coagulase negative Staphylococcus, 128ug/ml, >128ug/ml, and 64ug/ml, respectively.
Compared to the other 3 third generation cephalosporins, cefepime showed the lowest MIC90 against all isolates except Xanthomonas maltophilia, oxacillin resistant Gram-positive cocci. These high active in vitro test results are concluded to
indicate the
usefulness of cefepime for the treatment of Gram-negative bacilli and oxacillin sensitive Gram-Positive cocci including nosocomial ones.
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